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L2 Walker High Five Download Hit

protein fc epsilon receptor 1 (fcer1 or cd23) is a low affinity receptor for ige, which is expressed on mast cells and basophils. in its natural context, ige is responsible for activating these cells in immune defense. however, ige-fc is often used as an activating agent in research in cell culture. ige-fc is an affinity analog of ige, in which the ch2 domain is replaced by that of murine igg1. depending on the context, ige-fc can stimulate signal transduction in the absence of pre-bound ige, without causing ige aggregation [ 165 ]. the major difference between ige and ige-fc is that fcεri, the high-affinity receptor for ige, does not bind ige-fc. in the context of therapeutics, clinical data suggest that ige-fc has a potentially powerful therapeutic action in treatment-resistant asthmatic patients [ 165 ]. to this end, it was important to assess the levels of clinically important immunologic effector molecules following the blockade of fcεris in mouse models. we were interested to find what genes were upregulated and what the effect of ige-fc was on inflammatory gene expression profiles. the data show that a transcription factor gene, caspase recruitment domain 4 (card4), and chemokine-like receptor 6 (cklr6) are upregulated following the blockade of fcεri. card4/card6 upregulation was likely to be responsible for the prolonged airway inflammatory state that persists after treatment with ige-fc. this finding can be correlated with the clinical action of ige-fc in the treatment of refractory asthma [ 165 ]. in the long term, the gene set could be used for analysis of gene expression in a wide range of disorders and treatments.

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