Biochemical Engineering By D G Rao Free Download.55

The ethylene glycol ether family of compounds are commonly used to prevent freezing of stored foods, pharmaceuticals, and fertilizers, and as anti-freeze to prevent damage to aircraft engines. Ethylene glycol ethers are highly toxic to aquatic organisms, so that pharmaceuticals, pesticides, and industrial wastewater have to be treated before entering streams and lakes. Physical properties of these compounds also limit their use in some applications, such as the freeze-thaw resistance of polyurethane foam and the pour point of petroleum. Deglycolation is a useful way of removing ethylene glycol ethers from a water solution, which is used in various applications, such as: 1) the removal of ethylene glycol ethers from fuels; 2) the recovery of polymeric glycols from polymer wastes; 3) the production of renewable fuels or plastics from bio-crude oil; 4) the hydrolysis of glycol ethers; 5) the hydrolysis of polyethylene waste; 6) the detection of ethylene glycol ethers by GC/MS; and 7) the removal of ethylene glycol ethers from effluent [ 118 ].

The Pathway prototype consists of a modular pathway design, using standard parts (modules), with an integrated design to provide electrical power to each module. The devices are actuated by a microcontroller that controls the supply of electrical power to the modules, modulates signals between the modules to direct flow to the correct module, and is also able to monitor the modules so they are safe to use and provide data for future debugging and error analysis. The Pathway also includes a software implementation written in the Python language, which can be extended using the Python programming environment and developed using the free open source software development tool, Python Software Foundation’s ` Python 3.3 ` environment [ 135 ].

Nano-sized materials (nano-PTX) offers several desirable features to the chemotherapy of glioblastoma. At the molecular level, nano-PTX increases tumor targeting and leads to higher intratumoral level of PTX compared with free PTX [ 29 ]. Furthermore, the accumulation of nano-PTX in the tumors increases the retention time and decreases the rapid leakage into the blood [ 30 ]. These changes increase the survival of animals through the enhancement of the anti-tumor activities. For inducing efficient antitumor activity, nano-PTX functions as a carrier that delivers PTX molecules to cancer cells, whereas the nano-PTX could augment the biological effects of PTX [ 31 ]. In a recent report, the nano-PTX was studied in glioblastoma by targeting the three tumor-specific alterations (EGFRvIII, OX-40, and CD133). The nano-PTX enhanced the amount of PTX in tumors by 87% compared with the free PTX [ 32 ]. Other more important activities were also found for the nano-PTX. The nano-PTX enhances the cyto- and geno-toxicity of free PTX in U251 cells, which is the most aggressive human glioma cell line, even in the presence of the anti-cancer drug, temozolomide. Therefore, nano-PTX presents the capability of potentiating the anti-cancer activity of temozolomide in the inhibition of the tumor growth in a subcutaneous glioma animal model [ 33 ].
Nanotechnology is still at a basic level, and many studies should be conducted to ensure the safety of nanoparticle-based drug delivery systems. For instance, HNEs can change the chemical composition of drugs and degrade the activity of drugs. The nanoparticles could also trigger an adverse immune response to cellular components of the host. Therefore, it is necessary to conduct more systematic investigations to enhance the safety and quality of nanotechnology. The recently published works on nanotechnology hold immense promise in the designing of novel nanodevices for cancer therapy, and the free access to published papers will assist the researchers in improving the overall effectiveness of nanotechnology in the control of cancer and metastasis [ 34 ]. If nanotechnology can be applied in the field of cancer therapy, its further development will benefit the mankind in many other fields, such as agricultural, medical and economic development.
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