Solucionario De Introduccion A La Termodinamica En Ingenieria Quimica Van Ness 7ma Ed Pdf.pdfl

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Effect of the lymphotropic lymphangiogenic growth factor alphavbeta3 integrin on the survival and differentiation of keratinocytes.
Keratinocytes play important roles in skin diseases and wound healing. The cytokine alphavbeta3 integrin, which is found in invasive tumours, is of interest for pathology as a therapeutic target. We have shown that the growth factor alphavbeta3 integrin synergizes with the keratinocyte cytokine hepatocyte growth factor to promote the survival and proliferation of keratinocytes via the phosphoinositide 3 kinase pathway. In this study we have examined the effect of alphavbeta3 integrin on the survival and differentiation of keratinocytes. The addition of alphavbeta3 integrin to the culture medium during the first days of keratinocyte differentiation inhibited the terminal differentiation of the keratinocytes and increased their cell size. We propose that alphavbeta3 integrin stimulates the proliferation of keratinocytes by maintaining their growth and maintaining
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